breast tumor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13509	4-Vinylphenol		Apoptosis , Endogenous Metabolite
	4-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo.		Apoptosis , Endogenous Metabolite
T6540	Ibuprofen Lysine	Neoprofen	COX
	Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.		COX
T2345	PTC-209	PTC209,PTC 209	BMI-1 , Autophagy
	PTC-209 is a potent and selective BMI-1 inhibitor.		BMI-1 , Autophagy
T9497	Niraparib tosylate monohyrate		PARP
	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting...		PARP
T1394	Ibuprofen	Brufen,(±)-Ibuprofe,Motrin,Advil	COX
	Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu...		COX
T15249	Estrogen receptor modulator 1		Estrogen Receptor/ERR
	Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4...		Estrogen Receptor/ERR
TQ0219	MK-8033		c-Met/HGFR
	MK-8033 is a new and selective dual ATP competitive c-Met/Ron inhibitor (IC50: 1 nM Wt c-Met).		c-Met/HGFR
T3231	Niraparib	MK-4827	Apoptosis , Others , PARP
	Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis.		Apoptosis , Others , PARP
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
T1901	(E/Z)-TG003	TG003	BCL , CDK
	(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.		BCL , CDK
T3353	Niraparib hydrochloride	MK-4827 hydrochloride,MK-4827 (hydrochloride)	Apoptosis , Others , PARP
	Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of...		Apoptosis , Others , PARP
T8808L	LYN-1604 dihydrochloride	LYN-1604 2HCl（2216753-86-3 free base)	Apoptosis , Autophagy
	LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.		Apoptosis , Autophagy
T6010	Idarubicin hydrochloride	Idamycin,4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,4-Demethoxydaunorubicin hydrochloride,Idarubicin HCl,Zavedos	Topoisomerase , Antibacterial , Autophagy , Antifungal
	Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).		Topoisomerase , Antibacterial , Autophagy , Antifungal
T6892	Niraparib tosylate	MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate	Apoptosis , PARP
	Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.		Apoptosis , PARP
T4123	LYN-1604	LYN1604	Apoptosis , Autophagy
	LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.		Apoptosis , Autophagy
T6178	PTC-209 hydrobromide	PTC-209 HBr	BMI-1 , Autophagy
	PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).		BMI-1 , Autophagy
T5371	L-BUTHIONINE-(S,R)-SULFOXIMINE	L-Butionine sulfoximine	Others , Ferroptosis
	L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH.		Others , Ferroptosis
T70353	JG-231		HSP
	JG-231 is a JG-98 analog with anticancer activity.JG-231 inhibits the MDA-MB-231 xenograft tumor model of triple-negative breast cancer (TNBC).JG-231 inhibits the interaction of Hsp70-BAG3.JG-231 inhibits the MDA-MB-231 ...		HSP
T17098	Tilfrinib		BTK
	Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.		BTK
TN3651	Cichoriin		Others
	Cichoriin is a photosensitive compound, it could be used as herbal photosensitizing agent in treating benign breast tumor in rats.		Others